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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Cancer-associated fibroblasts promote the survival of irradiated nasopharyngeal carcinoma cells via the NF-κB pathway

Fig. 6

CAFs promoted the survival of irradiated NPC cells via the NF-κB pathway. Irradiation kills cancer cells via DNA damage. CAFs within TME promoted irradiated cancer cell survival by secretion of IL-8 to activate NF-κB signaling pathway, thus to enhance broken DNA repair and induced formation of radioresistance. Tranilast sensitized cancer cells to irradiation through the suppression of CAFs functionally, thus promoted irradiation-induced cell death

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