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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Overexpressed WDR3 induces the activation of Hippo pathway by interacting with GATA4 in pancreatic cancer

Fig. 1

Overexpression of WDR3 is correlated with an unfavorable prognosis in pancreatic cancer. a The GEPIA database was searched for WDR3 mRNA expression in several malignant cancers. Colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), liver hepatocellular carcinoma (LIHC), pancreatic adenocarcinoma (PAAD), and stomach adenocarcinoma (STAD). *, P < 0.05. b-c The GEPIA web tool was searched for disease-free survival (b) and overall survival (c) data for several malignant cancer patients with a high or low WDR3 expression level. P values are shown in the Fig. d. IHC images of WDR3 staining in TMA tissue sections are shown. The scale bars are shown in the Fig. e. Dot plots show the IHC scores of WDR3 expression for TMA tissue sections (normal pancreatic specimens: n = 25, PAAD TMA specimens: n = 31, P < 0.001). Statistical analyses were performed with D’Agostino & Pearson omnibus normality test. f and g Western blot analysis evaluated the expression of WDR3 in normal pancreatic ductal epithelial cells and pancreatic cancer cells (f). The protein expression levels of WDR3 were quantified with ImageJ software (g). GAPDH served as an internal reference

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