Fig. 6
From: METTL3-mediated m6A mRNA modification of FBXW7 suppresses lung adenocarcinoma
FBXW7 overexpression rescues tumor growth inhibition impeded by METTL3 knockdown in vivo. a Representative IHC staining images of METTL3 and FBXW7 expression in mouse tumors. b Tumors from nude mice. c Volume of HCC827 cell tumors xenografted with the indicated plasmids in nude mice measured at regular intervals. d Weight of HCC827 cell tumors xenografted with the indicated plasmids in nude mice. e Results based on TCGA and GEPIA database (http://gepia.cancer-pku.cn/index) showed the expression level of METTL3 in patients with lung adenocarcinoma (LUAD). f Kaplan-Meier analysis of METTL3 for overall survival, post-progression survival, and progression-free survival in LUAD (upper panels) and lung squamous cell carcinoma (LUSC) (bottom panels) patients. g Kaplan-Meier analysis of FBXW7 for OS in LUAD (upper panels) and LUSC (bottom panels) patients. Bar = mean ± SD. *p < 0.05; **p < 0.01