Fig. 3

Antitumor activity of selinexor and doxorubicin in DDLPS PDXs. a, Growth curves report the average tumor volume (±S.E.M.) in control and drug-treated animal groups (8 mice/group). The arrows in the figure indicate when drugs were administered. b, Pathologic evaluation of tumors obtained from untreated (Ctrl) and selinexor- or doxorubicin-treated mice at the end of treatment. c, Ki67 immunostaining of tumors obtained from untreated (Ctrl) and selinexor- or doxorubicin-treated mice at the end of treatments (upper panel) and quantification of Ki67 index (lower panel). Two tumors for each experimental group were analyzed. The symbols reported in the lower panel represent counted fields. ^*P < 0.05, ^**P < 0.01, ^***P < 0.005