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Table 2 Histomorphology and immunophenotypic profile of DDLPS PDX models

From: Selinexor versus doxorubicin in dedifferentiated liposarcoma PDXs: evidence of greater activity and apoptotic response dependent on p53 nuclear accumulation and survivin down‐regulation

 

LS-BZ-1

LS-GD-1

LS-BP-1

Human tumor

DDLPS, G3, myogenic dedifferentiation

DDLPS, G3, rhabdmyoblastic dedifferentiation

DDLPS, G3, myogenic dedifferentiation

H&E

Spindle cells and epitheliod cells

Spindle cells organized in fascicles, and rhabdoid cells

Spindle cells with small nuclei

CK1

Negative

Negative

Negative

CK3

Negative

Negative

Negative

EMA

Negative

Negative

Negative

Myogenin

Negative

Positive, diffuse

Negative

Actin 1A4

Negative

Positive, focal

Negative

Desmin

Negative

Positive, diffuse

Negative

H3K27me3

Positive

Positive

Positive

MDM2

Positive

Positive

Positive