TY - JOUR AU - Castelli, Serena AU - Ciccarone, Fabio AU - Tavian, Daniela AU - Ciriolo, Maria Rosa PY - 2021 DA - 2021/03/11 TI - ROS-dependent HIF1α activation under forced lipid catabolism entails glycolysis and mitophagy as mediators of higher proliferation rate in cervical cancer cells JO - Journal of Experimental & Clinical Cancer Research SP - 94 VL - 40 IS - 1 AB - In the last decades, the concept of metabolic rewiring as a cancer hallmark has been expanded beyond the “Warburg effect” and the importance of other metabolic routes, including lipid metabolism, has emerged. In cancer, lipids are not only a source of energy but are also required for the formation of membranes building blocks, signaling and post-translational modification of proteins. Since lipid metabolism contributes to the malignancy of cancer cells, it is an attractive target for therapeutic strategies. SN - 1756-9966 UR - https://doi.org/10.1186/s13046-021-01887-w DO - 10.1186/s13046-021-01887-w ID - Castelli2021 ER -