Fig. 5

Knockdown of FGF19 attenuates the LNMets of MT-LE HNSCC cells in orthotopic mice of tongue tumors. a, b Bioluminescence images of tongue tumors (a) and tongue tumor weight (b) in mice implanted with the indicated cells after a four-week inoculation. c Bioluminescence images of tumor dissemination in lymph nodes in mice implanted with the indicated cells after a four-week inoculation. d The protein levels of Vimentin in tumor xenografts from mice implanted with the indicated cells determined by IHC. In (a, c, d), representative images and quantitative data are shown in the left and right panels, respectively. *p < 0.05; **p < 0.01