Fig. 6

Inactivation of FGFR4 blocks the LNMets of MT-LE HNSCC cells in orthotopic mice of tongue tumors. a, b Bioluminescence images of tongue tumors (a) and tongue tumor weight (b) in mice receiving vehicle or H3B-6527 after 2 weeks of intratumoral treatment. c Bioluminescence images of tumor dissemination in lymph nodes in mice receiving vehicle or H3B-6527 after a two-week intratumoral treatment. d Histology of major organs at the endpoint of each treatment. e The protein levels of Vimentin in tumor xenografts from mice treated with or without H3B-6527 determined by IHC. In (a, c, d, e), representative images and quantitative data are shown in the left and right panels, respectively. *p < 0.05; **p < 0.01