Fig. 1

Expression and clinical significance of ZNF582-AS1 in ccRCC and its subcellular localization in ccRCC cells. a ZNF582-AS1 expression was downregulated in ccRCC tissues (n = 539) compared with in the adjacent normal renal tissues (n = 72) based on TCGA-KIRC data. b Lower ZNF582-AS1 expression was associated with advanced tumor stage (T1-T2 (n = 340), T3-T4 (n = 190)), higher pathological stage (Stage I-II (n = 322), Stage III-IV (n = 205)), distant metastasis (No (n = 440), Yes (n = 80)), and shorter OS (n = 530) and DFS (n = 485) based on TCGA-KIRC data. According to the median cutoff of ZNF582-AS1 expression, patients were divided into two groups for survival analysis. c The heights of the columns in the chart represented the log2-transformed fold changes (ccRCC tissue/ adjacent normal renal tissues) in ZNF582-AS1 expression in 62 patients with ccRCC. d ZNF582-AS1 expression was decreased in ccRCC tissues compared with in the adjacent normal renal tissues based on qRT-PCR results. e ZNF582-AS1 expression was downregulated in advanced tumor stage (T1-T2 (n = 41), T3-T4 (n = 21)) and distant metastatic (No (n = 43), Yes (n = 19)) ccRCC patients. f ZNF582-AS1 expression was generally decreased in ccRCC cells. g Subcellular localization of ZNF582-AS1 in ccRCC cells