Fig. 4
ZNF582-AS1 overexpression inhibited cell migratory and invasive ability in vitro and in vivo. a and b Wound healing assay determined the migratory distances of ZNF582-AS1-overexpressed OSRC2 and Caki-1 cells and their control cells. c and d Transwell migration and e and f invasion assays determined the migratory and invasive abilities of ZNF582-AS1-overexpressed OSRC2 and Caki-1 cells and their control cells. g and h The luciferase signals in the ZNF582-AS1-overexpressed group were remarkably lower than those in the control group. i There was no significant difference between the mice weight of ZNF582-AS1-overexpressed and control group. j and k The number and size of pulmonary metastases in the ZNF582-AS1-overexpressed group were significantly reduced compared with those in the control group. l and m ZNF582-AS1 overexpression increased E-cadherin expression and decreased N-cadherin expression in pulmonary metastases