Fig. 8

The schematic depiction of the positive feedback loop of HMGA1-TRIP13-c-Myc pathway. HMGA1 can induce the transcription and expression of TRIP13, therefore suppress FBXW7 expression and stabilize c-Myc, and eventually promote pCCA proliferation, migration, invasion, stemness and EMT. In the other side, c-Myc promoted HMGA1 and TRIP13 transcription, forming a positive feedback loop to amplify the effects of HMGA1-TRIP13 axis. Moreover, HMGA1 increased c-Myc expression via upregulating TCF family, which established another positive feedback pathway