Fig. 2
From: Underlying mechanisms and drug intervention strategies for the tumour microenvironment
Intervention of chemotherapy on the TME. Neoadjuvant chemotherapy can increase the density of myeloid suppressor cells. Oxaliplatin (OXP) can increase cancer infiltration and activation of CD8+ T cells and reduce cancer CD11b+F4/80high macrophages and spleen MDSCs. PG545 inhibits growth factor-mediated cell invasion, reduces the HB-EGF-induced phosphorylation of AKT, EGFR and ERK, and reduces the cancer burden. Gemcitabine (GEM) or paclitaxel (PTX) inhibited the EMT by reducing the frequency of CTCs and the logarithm of CTCs. Fludarabine has high selectivity for cells with low expression of X-inactivated specific transcription (XIST) and inhibits the growth of brain cancer cells