Fig. 7

Reversal of chemotherapy-elicited exosome-induced chemoresistance in vivo by EZH2 inhibitor tazemetostat. a A schematic diagram of the animal experiments. b Images of tumors in mice (n = 20). c Tumor onset and volume. Arrows indicate the time of treatments. d RT-qPCR analysis of miR-378a-3p or miR-378d in serum exosomes in the different treatment groups. e Tumor proteins were extracted from the different treatment groups and analyzed by western blotting. f Immunohistochemistry analysis of DKK3 and NUMB in the tumors of mice in the different treatment groups (n = 5). g A proposed model illustrating the role of chemotherapy-elicited exosomal miR-378a-3p and miR-378d in regulating chemoresistance in breast cancer cells. *p < 0.05, ** p < 0.01, *** p < 0.001