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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Cirsiliol targets tyrosine kinase 2 to inhibit esophageal squamous cell carcinoma growth in vitro and in vivo

Fig. 1

TYK2 expression is higher in ESCC and is negatively associated with patient survival. a Representative IHC staining images of ESCC tissue array using specific antibody for TYK2 in adjacent tissues and paired cancer tissues. Scale bar: 50 μm. b Analysis of TYK2 protein levels in ESCC tissue array according to staining results. TYK2 expression was valued as positivity. c Protein levels of TYK2 in ESCC tissue array based on clinical stages. d Survival rates of cancer patients with high or low protein levels of TYK2 in ESCC tumor microarray. Kaplan-Meier method was used to generate the survival curve. P < 0.05 was considered to be statistically significant. e The mRNA levels of TYK2 in different cancers based on the TCGA database. f The mRNA levels of TYK2 in ESCA (TCGA database) based on tumor histology. g The mRNA levels of TYK2 in ESCA (TCGA database) based on clinical stages. Due to some of the clinical stage information missing, the cases number in (g) is not the same with (f). Statistical analysis was performed using Student’s unpaired t-test in (b, c, e, and f); ANOVA in (g). Asterisks (*p < 0.05, **p < 0.01, ***p < 0.001) indicate a significant change. TPM, transcription per million

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