Fig. 3

Overexpressed TYK2 increased ESCC growth. a Cell viability of KYSE30, KYSE410 and KYSE510 after transfection with TYK2. b The representative colony images and Statistical analysis of ESCC cell lines. Scale bar: 200 μm. c The change of downstream signaling after TYK2 knockdown in KYSE140 and KYSE450 cells. d The change of downstream signaling after TYK2 overexpressed in KYSE30, KYSE410 and KYSE510 cells. Student’s unpaired t-test was used in (a and b). Asterisks (*p < 0.05, **p < 0.01) indicate a significant change