Fig. 8

ATAD2 is positively correlated with TGF-β1 signaling pathway in ESCC patients. a-e Correlation analysis of ATAD2 with TGF-β1 and epithelial-mesenchymal transition markers in ESCC patients. f Correlation analysis of expression of TGF-β1 and C/EBPβ in ESCC patients. g Mechanistic model of oncogenic function of ATAD2 in ESCC. ATAD2 interacts with C/EBPβ and enhances the latter’s nuclear translocation. ATAD2 interacts with C/EBPβ and enhances the latter’s nuclear translocation. C/EBPβ directly binds to the promoter region of TGF-β1 gene and facilitates its transcription and the subsequent activation of TGF-β signaling pathway induced epithelial-mesenchymal transition