Fig. 4
From: MZ1 co-operates with trastuzumab in HER2 positive breast cancer
Analysis of a transcriptomic array in cells treated with MZ1, trastuzumab or MZ1-trastuzumab (12 h). a Volcano plots (p-value (−log 10) vs Fold Change (log10)) of BT474 cells gene expression profile after 12 h treatment with MZ1, trastuzumab, and combination. Upregulated genes (FC > 2) are show in red and downregulated genes (FC < -2) are show in blue. b Venn diagram showing the number of downregulated genes in each treatment condition using p-value< 0.01 and FC < -2 as threshold. Bottom bar graph, functional analyses of the 186 altered genes after combination treatment using EnrichR Online Tool. Biological process gene ontologies (p < 0.01) grouped are shown. c Venn diagram showing the number of upregulated genes in each treatment condition using p-value < 0.01 and FC < -2 as threshold. Bottom bar graph, functional analyses of the 166 altered genes after combination treatment using EnrichR Online Tool. Biological process gene ontologies (p < 0.01) grouped are shown