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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Fibronectin as a multiregulatory molecule crucial in tumor matrisome: from structural and functional features to clinical practice in oncology

Fig. 3

FN1 as player in metastatic process and as diagnostic and therapeutic target. At the primary tumor site, the cancer cells and cancer associated fibroblasts (CAFs) deposit FN1. FN1 activates intracellular signaling, mediated by integrins, TLRs, Wnt/β catenin, and P13K, that lead to an increase of expression and secretion of FN1, MMPs, TGFβ. In parallel, FN1 is transferred by EVs. Cancer cells, with invasive capabilities, extravasate and reach a secondary organ, where tumor dormancy immune controlled may occur. Dormancy escape arises in the metastatic outgrowth in a permissive microenvironment with FN1 and collagen enriched ECM, affecting resistance to therapy. EDB isoform of FN1 is used as a biomarker for cancer diagnostic imaging and FN1 pathway as a target for therapeutic applications. Created with BioRender.com

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