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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Correction to: KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity

Fig. 6

HMGA1 is responsible for KIFC1-enhanced HCC proliferation and invasion. a and c HMGA1 restored clone formation inhibited by KIFC1 knockdown. The counts of clone cell numbers are shown in panel b. shKIFC1 was used the same sequences as sh33 (5′- ccagggctatcaaataaagaa-3′). Data are presented as the mean ± SD, * P < 0.01, ** P < 0.001. b and d HMGA1 restored the invasive ability inhibited by KIFC1 knockdown. The counts of invaded cell numbers are shown in panel D. Data are presented as the mean ± SD, * P < 0.01, ** P < 0.001. e Western blot assay indicated that the levels of mesenchymal markers (vimentin, Twist1) as well as MMP2, p-Stat3 decreased while the level of epithelial marker E-cadherin increased in KIFC1 knockdown 7701 cells. This phenomenon could be reversed by enforced expression of HMGA1 in 7701 KIFC1 knockdown cells

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