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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer

Fig. 1

NLRP7 protein with high expression level in CRC promotes tumor cell proliferation and metastasis. a NLRP7 mRNA levels in CRC tissues and the normal colorectal mucosa measured by qRT-PCR. b The protein levels of NLRP7 in CRC tissues and paired normal tissues measured by WB. N: non-tumor, T: tumor. c NLRP7 protein in CRC samples and corresponding adjacent normal tissues confirmed by IHC staining. Scale bars, 100 μm. d Kaplan–Meier survival analysis of patients with CRC according to NLRP7 expression (low: score < 6, high: score ≥ 6). Knockdown and overexpression of NLRP7 affected CRC cells proliferation as determined by (e) CCK8 assay, (f) colony formation ability and (g) cell apoptosis. The results of transwell assay of the (h) migration and (i) invasion for NLRP7 knockdown and overexpression CRC cells. Scale bars, 100 μm. ***P < 0.001, **P < 0.01, and *P < 0.05. NS: no significance

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