Fig. 6
MGAT5 involvement in mechanotransduction and cell migration rate control. One hundred sixty-six kilopascal is the optimal stiffness for integrin clustering controlled by MGAT5 glycosylation activity, focal adhesions (FA) turn-over and maturation (↻) and galectin 3 (Gal3) up-regulation. The resulting augmentation of FAK signalling increases expression of the mesenchymal marker ZEB-1 with subsequent increases of N-CAD and ZO-1 expressions leading to increased cell collective migration rate. ZEB-1 appears as a hub integrating signalling information from the SOX2 transcription circuit, independent of the RTKs [8] and the MGAT5 restricted mechanotransduction depending on ECM stiffness (S)