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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing

Fig. 6

MGAT5 involvement in mechanotransduction and cell migration rate control. One hundred sixty-six kilopascal is the optimal stiffness for integrin clustering controlled by MGAT5 glycosylation activity, focal adhesions (FA) turn-over and maturation () and galectin 3 (Gal3) up-regulation. The resulting augmentation of FAK signalling increases expression of the mesenchymal marker ZEB-1 with subsequent increases of N-CAD and ZO-1 expressions leading to increased cell collective migration rate. ZEB-1 appears as a hub integrating signalling information from the SOX2 transcription circuit, independent of the RTKs [8] and the MGAT5 restricted mechanotransduction depending on ECM stiffness (S)

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