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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Hypoxia-dependent expression of MAP17 coordinates the Warburg effect to tumor growth in hepatocellular carcinoma

Fig. 4

MAP17 regulates intracellular ROS to enhance the tumorigenic and glycolytic phenotypes. a The effect of MAP17 knockdown on ROS generation in SMCC-7721 and HCC-LM3 cells. b The effect of MAP17 or MAP17-PDZm overexpression on ROS generation in MHCC-97H cells. c-e Effects of MAP17 overexpression on glucose uptake (c), lactate release (d), and ECAR (e) were analyzed in the presence or absence of 10 mM N-acetyl cysteine (NAC) treatment. f The effect of MAP17 overexpression on cell proliferation of MHCC-97H cells in the presence or absence of 10 mM N-acetyl cysteine (NAC) treatment was determined by plate colony formation assay. *P < 0.05 and **P < 0.01

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