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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Novel LncRNA OXCT1-AS1 indicates poor prognosis and contributes to tumorigenesis by regulating miR-195/CDC25A axis in glioblastoma

Fig. 3

LncRNA OXCT1-AS1 is highly expressed in GBM and associated with prognosis. a OXCT1-AS1 expression patterns in different types of solid cancers from the TCGA database. b Kaplan-Meier curve analysis of OXCT1-AS1 based on TCGA GBM samples. c The expression of OXCT1-AS1 was examined by qRT-PCR in GBM tissues compared with that in corresponding adjacent normal tissues. d The ROC curve was constructed using SPSS. The area under the curve was 0.817. The sensitivity and specificity were 0.769 and 0.808, respectively. e The survival time of GBM patients was longer in the OXCT1-AS1 low expression group than in the high expression group. f The expression of CDC25A was examined by qRT-PCR in GBM tissues compared with that in corresponding adjacent normal tissues. GAPDH was used to normalize the gene expression. g The negative expression correlation between OXCT1-AS1 and miR-195 in GBM tissues was analysed. h Correlation between the expression of miR-195 and CDC25A. i Positive expression correlation between OXCT1-AS1 and CDC25A. The statistical bars represent SD (*p < 0.05, **p < 0.01, and ***p < 0.001)

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