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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Novel LncRNA OXCT1-AS1 indicates poor prognosis and contributes to tumorigenesis by regulating miR-195/CDC25A axis in glioblastoma

Fig. 7

OXCT1-AS1 functions as a ceRNA in GBM by sponging miR-195 and releasing downstream CDC25A. a Binding sequence between OXCT1-AS1 and miR-195. b The expression levels of miR-195 were examined by qRT-PCR in response to OXCT1-AS1 knockdown. c Binding sequence between miR-195 and CDC25A. d The luciferase assay was used to verify the binding between OXCT1-AS1 and miR-195. e The luciferase assay was used to verify the binding between miR-195 and CDC25A. f Western blotting confirmed that the antagomir-195 (AMO-195) reversed OXCT1-AS1 knockdown-induced CDC25A suppression. g, h Colony formation assays also showed that AMO-195 partly reversed OXCT1-AS1 knockdown-induced cell proliferation arrest. The bars represent SD (*p < 0.05, **p < 0.01, ***p < 0.001)

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