Fig. 3
From: SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia
Schematic representation of the crosstalk between hypoxia-inducible factor 1 (HIF-1) and semaphorins or their receptors in tumors. HIF-1 through the binding to the hypoxia responsive element (HRE) present in the promoter of semaphorin or neuropilin genes induces (green arrow) or blocks (red line) their expression. Inhibition of HIF-1 expression by Sema3F (red line) and induction of HIF-1 expression by neuropilin1 (green arrow) are also reported