The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway

Table 1 Relationship of circATP5B expression to clinical features of glioma patients

Clinical features		Samples (n = 70)	CircATP5B expression^a		P value
Clinical features		Samples (n = 70)	Low (n = 35)	High (n = 35)	P value
Sex	Male	38	18	20	P = 0.631
Sex	Female	32	17	15	P = 0.631
Age	≤ 50	28	16	12	P = 0.329
Age	> 50	42	19	23	P = 0.329
WHO grade	II	20	15	5	P = 0.002
	III	25	14	11
	IV	25	6	19
IDH status	Wild	33	9	24	P<0.001
IDH status	Mutant	37	26	11	P<0.001
1p/19q status	Codeletion	38	25	13	P = 0.004
1p/19q status	Non-codeletion	32	10	22	P = 0.004
H3F3A status	Wild	39	24	15	P = 0.03
H3F3A status	Mutant	31	11	20	P = 0.03
MGMT status	Methylation	42	26	16	P = 0.015
MGMT status	Unmethylation	28	9	19	P = 0.015

^a CircATP5B expression was detected by qRT-PCR and ranked from low to high. The high expression of circATP5B was defined as the expression level higher than the median expression level of circATP5B

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