Fig. 2

SLC6A8 expression is upregulated in TNBC tissues and associated with TNBC clinical progression. a Analysis of Slc6a8 expression in human breast cancers by tumor subtype based on data obtained from TCGA database (Normal, n = 112; Luminal, n = 815; HER2, n = 36; Basal-like TNBC, n = 114). b Slc6a8 mRNA expression was detected by qRT-PCR in human breast cancer tissues and normal counterparts (Normal, n = 60; Luminal, n = 67; HER2, n = 22; Basal-like TNBC, n = 60). c Kaplan-Meier survival analysis of the relationship between Slc6a8 expression and overall survival of TNBC patients based on TCGA data. d The ROC curve indicated the diagnostic value of SLC6A8 for TNBC. e Representative images of SLC6A8 abundances in adjacent non-cancerous tissues and TNBC tissues of different histopathological grades (Scale bars, 100 μm). f Analysis of the ratio of low or high SLC6A8 protein levels according to histological grades of 60 TNBC samples. (^*P < 0.05, ^***P < 0.001)