Skip to main content
Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress

Fig. 8

Enhanced creatine promotes tumorigenesis and attenuates oxidative stress in vivo. a Photos of the xenograft tumors. b Orthotopic tumor growth curve measured on a weekly basis. c The average tumor weight of each group was shown. d Average creatine concentrations of xenograft tumors. e Relative ROS levels were detected in tumor tissues by DCFH-DA staining. f, g SLC6A8, Ki-67, Bcl-2, Bax and cleaved Caspase-3 (cleaved CASP3) protein levels in tumor tissues were determined by western blot and IHC analysis (Scale bars, 100 μm). Data were presented as mean ± SD (*P < 0.05, **P < 0.01, ***P < 0.001)

Back to article page