Fig. 6
From: ROC1 promotes the malignant progression of bladder cancer by regulating p-IκBα/NF-κB signaling
ROC1 overexpression promoted BCa metastasis in vivo. a, b Representative image and summary of findings pertaining to metastatic nodules in nude mice administered LV-Vector or LV-ROC1-OE T24 cells via tail vein injection. The white arrows indicate pulmonary metastatic nodules. These values are expressed as the mean ± SD of 10 mice. ***P < 0.001, as determined using one-way ANOVA with Tukey’s post-hoc test. c Representative bioluminescence images of live animals, taken 8 weeks after tail vein injection. d Pathological lung-tissue sections were observed under a light microscope (40×). The black arrows point to lung-metastasis nodules. Scale bar, 1 mm. (E) Representative IHC-staining images of ROC1, uPAR, ICAM1, VCAM1, MMP9, and p65 in lung sections of mice injected with ROC1-overexpressing cells and control cells. Scale bar, 100 μm