Fig. 1
RvD1 reduces tumor growth in syngeneic mice transplanted with HPV-positive C3 cells. a Scheme showing in vivo transplantation and treatment protocols, as detailed in Materials and Methods. b Mean tumor volume from mice subcutaneously transplanted with C3 cells and treated with Vehicle or RvD1. n = 19 mice per group. **, P < 0.01; ****, P < 0.0001(two-way ANOVA and Sidak’s multiple comparisons test). c Representative image showing tumors at sacrifice. d Weight of tumors at sacrifice. n = 7–10 mice per group *, P < 0.05 (Unpaired t test with Welch’s correction). e Kaplan-Meier curve survival analysis reporting the time for tumors to reach a volume of 1500 mm3 (humanized endpoint). n = 18–20 mice per group **, P < 0.01 (Log-rank Mantel-Cox test). f Representative microsections of tumors biopsies from mice treated with vehicle or RvD1 and stained with antibodies against PCNA (proliferation marker), CASP-3 (apoptotic marker), and CD31 (blood vessels marker). g Semiquantitative proliferation score. n = 5–7 tumors per group. **, P < 0.01