Fig. 6

Higher monocyte infiltration predicts stronger immunity and better prognosis in CESC. a Gene sets significantly enriched (nominal P value < 1%) in CESC patients with higher monocyte infiltration compared to patients with high PMN infiltration, as determined by GSEA. Infiltration levels of immune population were determined by xCell analysis. Patients with the higher monocyte or PMN infiltration levels were selected for the analysis, while samples with overlapping higher monocytes and PMN were excluded. n = 41 monocytes high, n = 20 PMN high. Gene sets significantly enriched with a nominal P value < 1% were considered significant. b Tumor infiltration score of key immune cell populations in CESC samples with high monocytes or high PMN, as inferred by xCell. n = 41 monocytes high, n = 20 PMN high. *, P < 0.05; ***, P < 0.001; ****, P < 0.0001(two-way ANOVA and Sidak’s multiple comparisons test. c Kaplan-Meier curve survival analysis of CESC patients stratified as high monocytes (n = 41) vs high PMN (n = 20) predicted infiltrated cells accordingly to xCell. d Kaplan-Meier curve survival analysis of CESC patients stratified as high monocyte recruiting (n = 46) vs high PMN recruiting (n = 46) accordingly to TIP. Overlapping samples were excluded from the analysis. Clinical data were extracted from the TCGA CESC database and analyzed using the cBioportal software