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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5′-deoxy-5-fluorocytidine (5′-DFCR)

Fig. 6

Chemotherapy induced EMT status changes along with the increase of CDA and TYMP. a Immunoblotting of EMT markers E-cadherin and vimentin in A549 cells after single MTA and cisplatin and concurrent combination treatment. For comparison, the corresponding immunoblotting of CDA, TYMP and β-actin are also provided (same images as in Fig. 3b, top panel). b Graphical categorization of the immunoblots shown in A, N = 3, data are represented as mean. c Immunoblotting of CDA, TYMP and the EMT markers E-cadherin and vimentin in A549 cells after schedule-dependent MTA and cisplatin combination treatment. d Graphical categorization of the immunoblots shown in C, N = 3, data are represented as mean. e Immunoblotting of EMT markers E-cadherin and vimentin in H358 cells after single MTA and cisplatin and concurrent combination treatment. For comparison, the corresponding immunoblotting of CDA, TYMP and β-actin are also provided (same images as in Fig. 3b, second panel from the top). f Graphical categorization of the immunoblots shown in E, N = 2, data are represented as mean. g A549 cells undergo morphological changes after MTA and cisplatin combination treatment at recovery day 5 (RD5), (40×, total magnification)

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