Fig. 6

Exosomal circ_0072083 from resistant cells increases the resistance of sensitive glioma cells. a Exosomal circ_0072083 level was detected by qRT-PCR in resistance cells transfected with sh-circ_0072083 or sh-NC. b and c circ_0072083, miR-1252-5p, ALKBH5 and NANOG levels were examined in sensitive cells after treatment of exosome from resistant cells or PBS. IC50 of TMZ d, cell proliferation e and f, colony ability g, apoptosis h, migration i and j and invasion k were measured by CCK-8, colony formation, flow cytometry, wound healing and transwell analyses respectively in sensitive cells with stimulation of exosome from resistant cells or PBS after treatment of the indicated concentration of TMZ. ^*P < 0.05