Fig. 4

GSK3β and SFRP2 are the bona fide effector of miR-224 in vivo. a Tumor xenograft model. Cells were injected into the hindlimbs of nude mice (n = 6). Representative images of the tumors are shown. b Tumor volumes were measured on the indicated days. Data points are presented as the mean tumor volume ± SD. c Histopathology of xenograft tumors. The tumor sections were under H&E staining and IHC staining using antibody against Ki-67. d The percentage of Ki67 positive cells. Error bars represent mean ± SD from 3 independent experiments; * p < 0.05, ** p < 0.01