Table 1 Selected gene expression changes in PaCa 5061 xenograft tumors upon ITGAV KD. FDR adjusted P-values < 0.10 are highlighted (bold font)

 CDK8

1.8

0.007

0.108

 E2F4

−2.3

<  0.001

0.007

 LTBP1

− 2.61

0.0003

0.0201

 NEDD4L

−1.3

0.096

0.462

 PARD3

− 2.43

<  0.001

0.001

 PPM1A

2.42

0.002

0.051

 PPP1CA

−1.55

<  0.001

0.013

 PPP1CB

2.59

<  0.001

0.003

 RAP1B

1.5

0.0064

0.1065

 SERPINE1

−2.83

0.004

0.077

 SKIL

2.92

0.002

0.051

 SMAD1

−1.18

0.310

0.733

 SMAD2

1.09

0.809

0.958

 SMAD3

1.79

0.273

0.704

 SMAD4

−1.08

0.917

0.982

 SMAD6

−1.13

0.289

0.717

 SMAD7

1.06

0.505

0.851

 SMAD9

−1.01

0.595

0.887

 STUB1

−1.84

<  0.001

0.019

 TGFB1

−1.59

0.014

0.170

 TGFB2

3.61

0.003

0.071

 TGFBI

−0.11

0.065

0.384

 TGFBR1

1.68

<  0.001

0.015

 TGFBR2

1.22

0.971

0.994

 TGFBR3

−2.75

0.005

0.090

 ACTA2

−1.04

0.6051

0.8912

 ADAM10

2.26

0.003

0.063

 ADAM12

1.01

0.897

0.979

 BSG

−2.65

<  0.001

0.002

 CDH1

−1.21

0.3769

0.7813

 CDH2

−5.04

<  0.001

<  0.001

 FGFBP1

−1.86

0.007

0.107

 FLG

265.8

<  0.001

0.002

 FN1

−2.57

0.002

0.048

 HSPG2

−1.78

0.001

0.039

 JAG1

−3.05

<  0.001

0.005

 KLK13

2.06

0.001

0.043

 KLK7

3.18

0.008

0.125

 LAMA2

−1.61

0.001

0.028

 LAMA3

−6.57

<  0.001

0.003

 LAMA5

−1.74

0.072

0.404

 LAMB1

−4.02

<  0.001

<  0.001

 LAMC1

−1.99

0.001

0.039

 LUM

1.14

0.249

0.682

 MMP1

−2.59

0.160

0.577

 MMP10

−7.92

<  0.001

0.001

 MMP12

1.29

0.918

0.983

 MMP13

−1.42

0.200

0.629

 MMP14

−1.73

0.008

0.124

 MMP15

1.01

0.960

0.992

 MMP16

1.09

0.175

0.598

 MMP17

−1

0.851

0.968

 MMP2

1.06

0.159

0.576

 MMP20

1.01

0.562

0.875

 MMP24

1.03

0.990

0.998

 MMP3

1.07

0.635

0.903

 MMP7

2.95

<  0.001

0.010

 MMP9

−1

0.945

0.990

 MUC4

5.58

0.001

0.0366

 NID1

−2.3

<  0.001

0.009

 OCLN

17.35

<  0.001

0.010

 POSTN

1.03

0.1091

0.4901

 SNAI1

1.19

0.107

0.486

 SNAI2

−1.11

0.459

0.828

 SPP1

1.08

0.9279

0.9849

 TWIST1

1.08

0.313

0.734

 TWIST2

1.09

0.203

0.633

 VIM

1.2

0.1338

0.5344

 CD2

−1.08

0.312

0.734

 CD4

2.46

<  0.001

0.002

 CD46

2.88

0.001

0.029

 CD48

1.05

0.464

0.830

 CD55

1.75

0.016

0.177

 CD74

−1.05

0.891

0.978

 CNN2

−1.62

0.001

0.046

 CTSS

3.59

0.001

0.033

 DAPK1

3.58

0.001

0.027

 FYB

−5.95

0.036

0.279

 GBP2

7.67

<  0.001

0.012

 HLA-A

−1.09

0.306

0.730

 HLA-B

−1.13

0.439

0.818

 HLA-C

1.03

0.745

0.941

 HLA-DMA

1.58

0.007

0.110

 HLA-DMB

1.41

0.009

0.129

 HLA-DOA

1.26

0.009

0.129

 HLA-DOB

1.09

0.437

0.817

 HLA-DPA1

3.32

<  0.001

0.005

 HLA-DPB1

1.4

0.019

0.197

 HLA-DPB2

1.21

0.031

0.257

 HLA-DQA1

−1.14

0.294

0.721

 HLA-DQA2

1.77

0.008

0.123

 HLA-DQB1

−1.14

0.492

0.845

 HLA-DQB2

1.41

0.003

0.065

 HLA-DRA

14.81

<  0.001

0.004

 HLA-DRB1

19.95

0.001

0.025

 HLA-DRB4

12.38

<  0.001

0.005

 HLA-DRB5

3.45

<  0.001

0.002

 HLA-E

1.17

0.199

0.628

 HLA-G

1.64

0.048

0.328

 HLA-H

1.13

0.298

0.724

 ICAM1

1.71

0.065

0.385

 IFNG

−1.07

0.179

0.603

 IRF1

1.37

0.005

0.094

 IRF2

− 1.56

0.014

0.170

 JAK1

1.82

<  0.001

0.015

 KIF3B

−1.73

0.004

0.076

 LMO7

5.19

<  0.001

0.005

 MALT1

1.72

0.003

0.069

 MID1

−3.3

<  0.001

0.007

 MT2A

−2.36

0.002

0.049

 OAS1

1.78

0.014

0.169

 OSBPL1A

−2.52

<  0.001

0.010

 PAK1

−2.66

<  0.001

0.004

 PTAFR

−2.09

0.006

0.102

 RIPK2

2.56

0.020

0.205

 SLCO4C1

−2.93

0.001

0.040

 STAT1

2.58

<  0.001

0.019

 TIMP2

4.83

<  0.001

0.008

 TRIM22

2.28

<  0.001

0.004