Fig. 4

Effect of immune cell infiltrates on overall survival of metastatic UM patients. a-b Kaplan-Meier curves for overall survival according to the percentage of activated CD8 + Granzyme B+ T lymphocytes among the total CD8+ cells, calculated in the total area (a) or only in the intra-tumoral region (b). The median cutoff of CD8 + Granzyme B+ percentage was used to separate high and low infiltrate groups. c Kaplan-Meier curves for overall survival according to the combination of intra-tumoral CD3+ T lymphocytes and CD68+ macrophages densities. The median cutoff of each immune cell subset density was used to separate high and low infiltrate. d Evaluation of the Immunoscore as a prognostic biomarker in metastatic UM. Kaplan-Meier curves for overall survival according to Immunoscore: Immunoscore 0 (I0, n = 7); Immunoscore 1,2,3 (IntI, n = 9); Immunoscore 4 (I4, n = 5). Log-rank statistics were performed to determine significance, p values and the number of patients at risk for each time point are reported in each graph