Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities

Table 1 Tankyrase binding motifs of tankyrase substrates

Substrate	PARylated	Biological response	TBM	References
TRF1	Yes	Proteasomal degradation	RGCADG	[27, 32]
3BP2	Yes	Proteasomal degradation	RSPPDG	[17]
RNF146	Yes	Proteasomal degradation	TBM1: RESSADG TBM3: RSHRGEG TBM4: RSVAGG TBM5: RSRRPDG	[26, 33]
Axin1	Yes	Proteasomal degradation	TBM1: RPPVPG TBM2: RRSDLDLGYEPEG	[6]
PTEN	Yes	Proteasomal degradation	RYQEDG	[34]
Mcl-1	No	Inhibition of TNKS1/2 catalytic activity	RPPPIG	[35]
GMD	No	Inhibition of TNKS1/2 catalytic activity	RGSGDG	[32, 36]
PEX14	No	Scaffolding function	TBM1: RMEVQG TBM2: RRGGDG	[14]
ATG9	No	Scaffolding function	RLPGLG	[14]
MERIT40	Yes	Scaffolding function	TBM1: RSNPEG TBM2: RSEGEG	[37, 38]
LKB1	Yes	Complexes disruption	TBM1: RAKLIG TBM2: RRIPNG	[39]

ISSN: 1756-9966