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Table 1 Tankyrase binding motifs of tankyrase substrates

From: Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities

Substrate PARylated Biological response TBM References
TRF1 Yes Proteasomal degradation RGCADG [27, 32]
3BP2 Yes Proteasomal degradation RSPPDG [17]
RNF146 Yes Proteasomal degradation TBM1: RESSADG
TBM3: RSHRGEG
TBM4: RSVAGG
TBM5: RSRRPDG
[26, 33]
Axin1 Yes Proteasomal degradation TBM1: RPPVPG
TBM2: RRSDLDLGYEPEG
[6]
PTEN Yes Proteasomal degradation RYQEDG [34]
Mcl-1 No Inhibition of TNKS1/2 catalytic activity RPPPIG [35]
GMD No Inhibition of TNKS1/2 catalytic activity RGSGDG [32, 36]
PEX14 No Scaffolding function TBM1: RMEVQG
TBM2: RRGGDG
[14]
ATG9 No Scaffolding function RLPGLG [14]
MERIT40 Yes Scaffolding function TBM1: RSNPEG
TBM2: RSEGEG
[37, 38]
LKB1 Yes Complexes disruption TBM1: RAKLIG
TBM2: RRIPNG
[39]