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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: HSP90-dependent PUS7 overexpression facilitates the metastasis of colorectal cancer cells by regulating LASP1 abundance

Fig. 5

PUS7 promotes CRC metastasis via the upregulation of the expression of LASP1. a WB assessment of LASP1 expression in the specified cells. b Images illustrating the Transwell assay in the specified cell lines and respective statistical analysis. c DLD1 cells were transfected with shPUS7 or LASP1. The expression levels of PUS7 and LASP1 were verified by WB analysis and qPCR. d HCT-8 cells were transfected with PUS7 or shLASP1. The expression levels of PUS7 and LASP1 were verified by WB analysis and qPCR. e, f Images illustrating the Transwell assay for the specified cell lines and respective statistical analysis. g Images illustrating the H&E-stained lung tissues from the diverse groups, the incidence of lung metastasis, and statistical analysis (n = 15 mice per group for DLD1 cells and n = 10 mice per group for HCT-8 cells). All the data are shown as the mean ± s.d. *P < 0.05, **P < 0.01, ***P < 0.001

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