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Table 2 Univariate and multivariate analysis of the factors associated with overall survival in CRC patients

From: HSP90-dependent PUS7 overexpression facilitates the metastasis of colorectal cancer cells by regulating LASP1 abundance

Variables

OS

p

Hazard Ratio

95% confidence interval

Univariate analysis

 Age (<  60 vs. ≥ 60)

0.238

1.422

0.792–2.554

 Gender (Male vs. Female)

0.374

1.274

0.746–2.177

 Pathological stage (I-II vs. III)

< 0.001

2.964

1.671–5.259

 tumor size (<  5 cm vs. ≥ 5 cm)

0.086

1.605

0.935–2.755

 T classification (T2-T3 vs. T4)

0.207

1.539

0.788–3.007

 N classification (N0 vs. N1-N2)

< 0.001

2.912

1.668–5.082

 M classification (absent vs present)

0.099

2.380

0.850–6.667

 Clinical stage (I-II vs III-IV)

< 0.001

3.060

1.720–5.442

 HSP90

< 0.001

6.869

2.725–17.317

 PUS7

< 0.001

3.470

1.876–6.419

 LASP1

< 0.001

6.974

3.133–15.527

Multivariate analysis

 Pathological stage (I-II vs. III)

< 0.001

3.867

1.870–7.996

 N classification (N0 vs. N1-N2)

0.063

0.706

0.162–3.080

 Clinical stage (I-II vs III-IV)

0.734

3.117

0.682–14.243

 HSP90 (high vs. low)

0.336

1.959

0.579–6.628

 PUS7 (high vs. low)

0.003

3.304

1.535–7.108

 LASP1 (high vs. low)

0.019

2.923

1.136–7.515