Fig. 1
From: N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies
Function and mechanisms of N6-methyladenosine (m6A) regulators. The m6A modification is deposited by methyltransferase complex including METTL3, METTL14, WTAP, VIRMA, RBM15, and ZC3H13, or by METTL16 alone. The m6A modification is removed by demethylase FTO or ALKBH5. Readers could recognize and affect the fate of m6A modified RNA molecules, including RNA splicing, export, translation, decay, and so on