Table 1 Involvement of BACE1/2 in different types of cancer where the inhibition of these enzymes curbed tumor proliferation and/or progression.
Cancer | BACE1 inhibition | BACE2 inhibition | BACE1/2 inhibition |
|---|---|---|---|
Melanoma | - | Decreased proliferation of metastatic melanoma cells [44] and tumor volume in ocular melanoma [74] | Decreased proliferation and enhance chemosensitivity of melanoma cells [44]; reduced brain metastasis [69] and reduce tumor volume [48] |
Pancreas | - | - | Reduced cancer cell proliferation [49] |
Glioma | Reduced tumor volume and synergized with radiotherapy [73] | Reduced cancer cell proliferation, migration and invasion [46]; reduced tumor volume and enhanced sensitivity to radiotherapy [45] | - |