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Table 1 Involvement of BACE1/2 in different types of cancer where the inhibition of these enzymes curbed tumor proliferation and/or progression.

From: The emerging role of β-secretases in cancer

Cancer BACE1 inhibition BACE2 inhibition BACE1/2
Melanoma - Decreased proliferation of metastatic melanoma cells [44] and tumor volume in ocular melanoma [74] Decreased proliferation and enhance chemosensitivity of melanoma cells [44]; reduced brain metastasis [69] and reduce tumor volume [48]
Pancreas - - Reduced cancer cell proliferation [49]
Glioma Reduced tumor volume and synergized with radiotherapy [73] Reduced cancer cell proliferation, migration and invasion [46]; reduced tumor volume and enhanced sensitivity to radiotherapy [45] -