Fig. 1
From: Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma
High expression of DEC2 induced tumor dormancy of the primary SACC in nude mice. a and b Tumor volume (a) and immunohistochemical staining of DEC2 (b) in atRA treatment and control group. c Fold change in mRNA expression of NR2F1, P27, P53, DEC2, CDK4, P38 and ERK, and the protein expression of DEC2 after atRA treatment compared to control group. d DEC2 over expression was confirmed by QPCR, WB and immunofluorescence in SACC-83 cells. e and f SACC-83 cells with or without DEC2 overexpression were injected into nude mice subcutaneously to observe tumor development. Tumor volumes were determined (e) and the expression of DEC2, HIF1α and Ki-67 were detected by immunohistochemical staining (f). Error bars represent the mean ± SD of triplicate experiments. (*P < 0 .05, **P < 0.01, ***P < 0 .001)