Fig. 9

Combination of GEN and STAT3 shRNA inhibited xenograft growth by co-injection of SKOV3-derived OCSLCs and THP-1 macrophages. The nude mouse xenograft model using co-injection with OCSLCs/THP-1 macrophages was treated with GEN (50 mg/kg) and Ad-shSTAT3 alone or in combination. The size (a) volume (b), weight (c), histological examination (HE staining) and the expression of CD68, IL-8 and p-STAT3 (immunohistochemical staining) (d) of xenografts were shown (scale bar, 100 μm). *P < 0.05, vs the model control group; ^#P < 0.05, vs treated with GEN (50 mg/kg) or Ad-shSTAT3 alone (means±SD, n = 4)