The potential role of the extracellular matrix in the activity of trabectedin in UPS and L-sarcoma: evidences from a patient‐derived primary culture case series in tridimensional and zebrafish models

Table 1 Clinical pathologic characteristics of UPS and L-sarcoma patients enrolled in the study

Patient	Sex	Age at surgery (years)	site	Size of major axis (cm)	Histological subtype	IHC analysis	Molecular cytogenetic analysis	Grade	Tumor	Surgical margins	Radiotherapy post-surgery	Chemotherapy post-surgery	Follow up (months)
S1	Female	81	lower arm	13	UPS	na	MDM2/ CEP12 = 1 FUS (16p11)˂10 %	G3	Primary tumor	R1	Yes	No	26
S2	Female	83	gluteus	2.5 ;1	DDLPS	na	MDM2/ CEP12 = 2	G3	Local recurrence	R1	Yes	No	46
S3	Female	72	lower arm	15	DDLPS	na	MDM2/ CEP12 = 2 FUS (16p11)˂10 %	G3	Local recurrence	R0	No	No	14
S4	Female	61	thigh	20	ALT/WDLPS	na	MDM2/ CEP12 = 2	G3	Primary tumor	R0	No	No	11
S5	Female	77	retroperitoneum	10	LMS	SMA + desmin +	MDM2/ CEP12 = 1	G2	Primary tumor	R1	No	No	10
S6	Female	71	retroperitoneum	10	ALT/WDLPS	na	MDM2/ CEP12 = 2	G1	Primary tumor	R1	No	No	12
S7	Male	56	trunk	15	ALT/WDLPS	na	MDM2/ CEP12 = 2	G1	Primary tumor	R0	No	No	2
S8	Female	78	thigh	6	UPS	SMA + CD31 – CD34 – S100 –cytokeratins- desmin - CD117 -	MDM2/ CEP12 = 1	G3	Primary tumor	R0	Yes	No	9
S9	Female	57	abdomen	9	DDLPS	na	MDM2/ CEP12 = 2	G3	Primary tumor	R1	No	No	6
S10	Female	64	thigh	7	PLS	na	MDM2/ CEP12 = 1	G3	Primary tumor	R1	No	Yes	4

IHC immunohistochemical analysis, n/a not applicable, SMA smooth muscle actin, R0 microscopically margin-negative resection, R1 microscopically margin-positive resection

ISSN: 1756-9966