Table 1 Frequency of mutations in the RAS-MAPK genes of different adult and childhood cancers (source: COSMIC database, April 6th, 2020)

Receptor

ALK

F1174L, R1275Q, R1245V

6.3

0.8

7.3

5.7

5.6

4.4

9.1

Protein adaptor

SHC1

E343D

0.1

0.1

0.6

2.0

0.2

0.7

1.0

GRB2

0.4

2.2

0.6

1.0

0.3

0.9

PTPN11

Mutations in SH2 and PTP domains

1.0

1.7

1.3

1.7

4.7

0.9

2.4

SOS

SOS1

N993Sfs*5

0.1

0.7

3.3

3.5

1.3

2.1

3.7

RAS

N-RAS

Q61K/E/L, G13R, A59T

0.7

1.0

0.5

3.7

9.5

0.8

15.0

K-RAS

G12V

0.8

1.4

32.4

4.9

14.8

2.8

H-RAS

Q61K

0.1

0.0

0.6

0.9

0.2

0.5

10.6

RAF

BRAF

V600E. F595L. R719P

0.1

4.7

2.1

12.3

8.2

2.2

41.0

RAF1

L397V

0.1

0.3

1.6

2.3

0.6

1.0

3.1

ARAF

0.2

0.6

2.0

0.3

1.4

1.9

MEK1/2

MAP2K1

K57N

0.3

1.8

1.9

2.2

0.7

4.7

MAP2K2

c.920-66G > T

0.1

0.1

0.8

1.3

0.5

0.6

2.1

ERK1/2

MAPK3

E367D

0.1

0.1

0.4

1.0

0.2

0.3

1.4

MAPK1

0.4

1.6

1.3

1.1

0.3

1.5

NF

NF1

Inactivating nonsense mutations

1.2

7.2

6.1

9.5

3.5

7.2

16.8