Fig. 3
From: Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment
Inhibition of SERT blocks activation of the mTOR pathway. a WB for mTOR, S6K and SLC1A5 in HCT116 and SW480 cells treated with increasing concentrations of serotonin (25–100 μM) for 12 h. b WB for mTOR, S6K and SLC1A5 in HCT116 and SW480 cells transfected with siSERT or negative siNC for 48 h. c WB for mTOR, S6K and SLC1A5 in HCT116 and SW480 cells treated with increasing concentrations (5–15 μM) and process time (0–48 h) of sertraline