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Fig. 10 | Journal of Experimental & Clinical Cancer Research

Fig. 10

From: RETRACTED ARTICLE: Exosomal DLX6-AS1 from hepatocellular carcinoma cells induces M2 macrophage polarization to promote migration and invasion in hepatocellular carcinoma through microRNA-15a-5p/CXCL17 axis

Fig. 10

DLX6-AS1 mediates miR-15a-5p to target CXCL17 to drive migration, invasion and EMT in HCC. a. RT-qPCR analysis of CXCL17 expression in macrophages; b. RT-qPCR detection of M2 macrophages markers (CD206, CD163, CCL17 and CCL18); c. RT-qPCR detection of M1 macrophages markers (TNF-α, IL-6 and TGF-β); d. Transwell assay tested the migration and invasion of SMMC-7721 cells; e. Transwell assay tested the migration and invasion of HepG2 cells; f/g. E-cadherin, N-cadherin, vimentin and MMP7 mRNA expression in SMMC-7721 and HepG2 cells; data were expressed as mean ± standard deviation (repetition = 3) and evaluated by One-way AVONA and Tukey’s test. ^ P < 0.05 compared with the oe-DLX6-AS1-exo + si-NC group; + P < 0.05 compared with theoe-DLX6-AS1-exo + si-NC+ M group

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