Fig. 1
From: Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance
Pharmacokinetic and pharmacodynamic factors leading to tumor chemoresistance and related mechanisms. Various factors, including many biomolecular mechanisms, are involved in the induction of chemoresistance through influencing the pharmacokinetics and pharmacodynamics factors of chemotherapy drugs. Epigenetic regulation, particularly through SEs, plays an important role in this process