Fig. 3
From: Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance
The role that SEs play in tumor chemoresistance and the factors that influence the activity of the SE complex. SEs can induce tumor chemoresistance by regulating molecular biological factors such as the formation of CSCs, cellular plasticity, the microenvironment, genes associated with chemoresistance, tumor immunity, and ncRNAs. A variety of complex components are involved in regulating the activity of SEs, including H3K27ac, BRD4, and CDKs, through which many molecules affect SE formation and activity in the process of acquiring chemoresistance. Related inhibitors can also restrain the occurrence of chemoresistance