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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1

Fig. 5

Mechanisms of SRSF1-regulated exon 3 of PTPMT1 inclusion. a Schematic representation of the PTPMT1 minigene construct. Two fragments (E3F1 and E3F2) each containing potential SRSF1 binding motifs are marked. Note that potential binding motifs of SRSF1 reported in article are marked in red, predicted motifs based on RNA-seq are marked in blue, and the overlap was marked in yellow. b Diagram of PTPMT1 minigene deletion mutant plasmids. c In vivo splicing analysis of PTPMT1 minigene and indicated deletion mutants in 293 T cells. d In/Ex index are shown at the bottom of the gel

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